good and bad cholesterol
good and bad cholesterol

About Cholesterol:

Cholesterol is found in our blood in two state that are, Bad Cholesterol (low-density lipoproteins, LDL) and Good Cholesterol (high-density lipoproteins, HDL).

Bed Cholesterol (LDL), if in excess in your blood it will start sticking with your arteries which causes them getting hard and by the time bed cholesterol covering your arteries this will start blocking your blood in result you can have heart attack.

Good Cholesterol (HDL) has the inverse effect as compare with LDL, these are the packets of fats and proteins which takes extra cholesterol in your blood to provided cholesterol where they are needed in your body so this reduces the chance of heart attack.

New Research for Good Cholesterol:

ApoA-I molecules form a cage  structure that surrounds the HDL: courtesy of W. Sean Davidson, University of Cincinnati

Due to this great functionality of Good Cholesterol, scientists are working to create drugs which helps rise your cholesterol level in your blood, because they still unable to find that why good cholesterol have this protective effect, it is difficult to create a drug so far.

For studying good cholesterol scientist uses synthetic cholesterol made in test tubes to study the biology and structure of it. Dr. W. Sean Davidson, professor at the University of Cincinnati and his team created first ever 3d model of Human cholesterol.

Dr. Davidson says “Scientists could more fully understand the protective effects of HDL if they knew what naturally occurring HDL looks like. This could help them discover how HDL interacts with other factors in human blood.

Davidson also says “the ApoA-I proteins surround the HDL particle much like the black lines of a basketball. This cage-like structure holds fats inside while also making them accessible to other proteins.”

Davidson proposed model of human HDL is similar to the model presented for the synthetic HDL, he suggests that proteins have small room to attach HDL. He also says that isolating human HDL, we were able to focus on the broad range of HDL particles actually circulating in humans. The work has important implications for understanding the interactions between HDL and other molecules that help prevent cardiovascular disease.